3 products were found matching "5690-03-9"!
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Splitomycin
Item number: AG-CR1-0088-M001
Potent cell permeable and selective inhibitor of yeast NAD-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated...
| Keywords: | 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one, 1-Naphthalen propanoic acid |
| Application: | HDAC inhibitor |
| CAS | 5690-03-9 |
| MW: | 198,2 D |
From 33.00€
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Splitomicin
Item number: Cay13168-10
Sir2p, the product of the SIR2 gene, is a conserved NAD+-dependent histone deacetylase (HDAC) involved in the regulation of the lifespan in yeast. It plays roles in silencing gene expression and negatively regulates the initiation of DNA replication. Splitomicin is a small molecule inhibitor of Sir2p histone...
| Keywords: | 1-Naphthalenepropanoic Acid, 1,2-dihydro-3H-naphtho[2,1-b]pyran-3-one |
| Application: | SIR2p inhibitor |
| CAS | 5690-03-9 |
| MW: | 198.2 D |
From 43.00€
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Splitomicin
Item number: LKT-S6247.10
Splitomicin is a cell-permeable lactone that acts as an inhibitor of sirtuins 1 and 2 (SIRT1, SIRT2), sirtuins are considered class III histone deacetylases (HDACs). Splitomicin displays anti-inflammatory, antioxidative, and antithrombotic activities. In vitro, splitomicin promotes translocation of FOXO3a,...
| Application: | SIRT1 / SIRT2 inhibitor |
| CAS | 5690-03-9 |
| MW: | 198.22 D |
From 90.00€
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