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Item number: TGM-T6051-100mg

Description: Orteronel ((S)-Orteronel)(TAK-700) was selected as a candidate for clinical evaluation. orteronel (TAK-700) is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer. Target: P450. Smiles: CNC(=O)c1ccc2cc(ccc2c1)[C@@]1(O)CCn2cncc12. References: Yamaoka M, et al....

Keywords:	(S)-Orteronel, TAK-700
Application:	Targets steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase (CYP17A)
CAS	566939-85-3
MW:	307.35 D

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Orteronel

Item number: Cay24191-10

Orteronel is a non-steroidal inhibitor of the 17,20-lyase activity of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 48 and 19 nM for the rat and human enzyme, respectively), which is the CYP17A1 activity that converts progestogens into androgens. Orteronel is selective for the 17,20-lyase activity of CYP17A1...

Keywords:	TAK-700, 6-[(7S)-6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide
Application:	Androgen synthesis (CYP17A1 17,20-lyase) inhibitor
CAS	566939-85-3
MW:	307.3 D

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