Description: 5,6-Dihydrouridine, a modified base, is located in conserved positions within the D-loop of tRNA in Eukaryota, Bacteria, and some Archaea. Target: Endogenous Metabolite. Smiles: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1CCC(=O)NC1=O. References: Kasprzak JM, et al. Molecular evolution of dihydrouridine...

5,6-Dihydrouridine is a pyrimidine nucleoside and derivative of uridine (Cay-20300). It is present in, and provides conformational flexibility to, tRNA from bacteria, eukaryotes, and some archaea. 5,6-Dihydrouridine inhibits E. coli cytidine deaminase in a cell-free assay (Ki = 3.4 µM). Serum levels of...