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Securinine (Securinan-11-one)
Item number: S0380.50
Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity. Synonyms:...
| CAS | 5610-40-2 |
From 374.00€
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Securinine
Item number: LKT-S1609.100
A gamma-aminobutyric acid (GABA) receptor antagonist. Recently, it was found to induce apoptosis in human leukemia HL-60 cells.
| Keywords: | Securinan-11-one |
| Application: | GABA receptor antagonist |
| CAS | 5610-40-2 |
| MW: | 217,26 D |
From 146.00€
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(-)-Securinine
Item number: Cay24902-10
(-)-Securinine is an alkaloid originally isolated from S. suffructicosa. It reduces proliferation of SW480 colon adenocarcinoma cells in a dose- and time-dependent manner via increased Beclin 1 expression and induction of autophagy. It decreases viability of HL-60 leukemia cells (IC50s = 47.88, 23.85, and 18.87 µM...
| Keywords: | L-Securinine, NSC 107413, (6S,11aR,11bS)-9,10,11,11a-tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one |
| Application: | Alkaloid |
| CAS | 5610-40-2 |
| MW: | 217.3 D |
From 122.00€
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(-)-Securinine
Item number: TGM-T3S2100-100mg
Description: (-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist. Target: GABA Receptor. Smiles: [H][C@]12C[C@@]3(OC(=O)C=C3C=C1)[C@@]1([H])CCCCN21. References: Stefanowicz-Hajduk J, et al. Securinine from Phyllanthus glaucus Induces Cell Cycle Arrest and Apoptosis in Human...
| Keywords: | Securinine |
| CAS | 5610-40-2 |
| MW: | 217.26 D |
From 48.00€
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