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A-674563
Item number: Cay18715-1
Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBalpha, beta, gamma) modulate cell proliferation, metabolism, and survival, as well as angiogenesis. A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki = 11 nM for Akt1). It shows inhibitory...
| Keywords: | alphaS-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-benzeneethanamine |
| Application: | Akt inhibitor |
| CAS | 552325-73-2 |
| MW: | 358.4 D |
From 73.00€
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A-674563 (free base)
Item number: AG-CR1-3680-M005
White to off-white solid. Soluble in DMF (20mg/ml) or DMSO (10mg/ml). Chemical. CAS: 552325-73-2. Formula: C22H22N4O. MW: 358.4. Synthetic. A-674563 is a potent, ATP-competitive, reversible and orally available Akt1 inhibitor with an IC50 of 11nM. Binds to the ATP site of the AKT kinase domain, inhibiting...
| Keywords: | alphaS-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-benzeneethanamine |
| CAS | 552325-73-2 |
| MW: | 358,4 D |
From 50.00€
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A-674563
Item number: TGM-T6139-1mg
Description: A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. Target: ERK, Akt, CDK, GSK-3, PKA. Smiles: Cl.Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1. References: Luo Y, et al, Mol Cancer Ther, 2005, 4(6), 977-986.
| Keywords: | A674563 |
| Application: | Akt inhibitor |
| CAS | 552325-73-2 |
| MW: | 358.44 D |
From 45.00€
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