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AP-18
AP-18

Item number: Cay11912-10

AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 µM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro.Formal Name: 4-(4-chlorophenyl)-3-methyl-3-buten-2-one, oxime. CAS Number:...
Keywords: 4-(4-chlorophenyl)-3-methyl-3-buten-2-one, oxime
Application: TRPA1 inhibitor
CAS 55224-94-7
MW: 209.7 D
From 89.00€ *
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AP 18
AP 18

Item number: TGM-T21543-100mg

Description: AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 µM Cinnamaldehyde with an IC50 of 3.1 µM and 4.5 µM for human and mouse TRPA1, respectively. AP-18 could reverse complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 could...
CAS 55224-94-7
MW: 209.67 D
From 40.00€ *
Review