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Item number: Cay43153-10

Drofenine is an antagonist of M1 muscarinic acetylcholine receptors (mAChRs). It inhibits carbachol-induced inositol phosphate accumulation in isolated guinea pig cortical slices, which endogenously express M1 muscarinic receptors (pA2 = 8.15). Drofenine also inhibits butyrylcholinesterase (BChE) isolated from human...

Keywords:	Hexahydroadiphenine, NSC 42559, a-cyclohexyl-benzeneacetic acid, 2-(diethylamino)ethyl ester, monohydrochloride
Application:	M1 muscarinic receptor antagonist
CAS	548-66-3
MW:	353.93 D

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Drofenine hydrochloride

Item number: TGM-T0713-1mL

Description: Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) is an effective competitive inhibitor of BChE (Ki value: 3 uM). Target: AChE. Smiles: Cl.CCN(CC)CCOC(=O)C(C1CCCCC1)c1ccccc1. References: Pawelczyk E, et al. Acta Pol Pharm. 1971, 28(6):594-602.

Keywords:	Hexahydroadiphenine hydrochloride
CAS	548-66-3
MW:	353.93 D

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