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Item number: Cay11997-1

JNJ-10181457 is an antagonist of histamine H3 receptors (Kis = 1.17 and 7.08 nM for human and rat receptors, respectively). It increases extracellular norepinephrine and acetylcholine levels in the frontal cortex of rats when administered subcutaneously at a dose of 10 mg/kg. JNJ-10181457 (1.25-10 mg/kg, p.o.)...

Keywords:	RWJ 662733, 4-[[3-[4-(1-piperidinyl)-1-butyn-1-yl]phenyl]methyl]-morpholine, dihydrochloride
Application:	H3 Receptor antagonist
CAS	544707-20-2
MW:	385.4 D

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JNJ-10181457 (hydrochloride)

Item number: TGM-T37220-1mg

Description: JNJ-10181457 (hydrochloride) is a non-imidazole H3 receptor antagonist that is brain-penetrating and selective, increasing NE and acetylcholine concentrations within the rat frontal cortex. Can be used for neurological-related research. Target: Others. Smiles: N1(CCCCC1)CCC#CC2=CC=CC(CN3CCOCC3)=C2.Cl.Cl

Application:	H3 Receptor antagonist
CAS	544707-20-2
MW:	385.37 D

From 106.00€ *

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