Etretinate is a second-generation retinoid previously used systemically to manage psoriasis but withdrawn due to teratogenicity. Etretinate alters cAMP signaling, which may be defective in psoriasis.Formal Name: (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid, ethyl ester....

Etretinate, also known as Tegison, is a synthetic aromatic analog of retinoic acid. It is used for treatment of severe recalcitrant psoriasis, parakeratotic skin disorders, chemoprevention of skin cancer and other neoplasia.

Description: Etretinate (Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells....