Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...

Isolated from Streptomyces hygroscopicus. Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the molecular target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an...

Soluble in DMSO at 200 mg/mL, soluble in ethanol at 50 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility

Macrolide originally produced by Streptomyces, mTOR inhibitor.

Rapamycin is a bacterial macrolide with antifungal and immunosuppressant activities , (1). Rapamycin forms a complex with the immunophilin FKBP12 which then inhibits the activity of FRAP/mTOR (TOR in yeast) (2,3). Rapamycin treatment of cells leads to the dephosphorylation and inactivation of p70 S6 kinase....