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CGP 57380
Item number: TGM-T6440-100mg
Description: CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 µM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. Target: Apoptosis, MNK. Smiles: Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12. References: Knauf U, et al. Mol Cell Biol. 2001, (16), 5500-5511.
| Keywords: | MNK1 Inhibitor |
| Application: | MAPK-interacting kinase 1 inhibitor |
| CAS | 522629-08-9 |
| MW: | 244.23 D |
From 40.00€
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CGP 57380
Item number: Cay13322-5
CGP 57380 is a selective inhibitor of MAP kinase-interacting kinase 1 (MNK1) in vitro (IC50 = 2.2 µM), with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. It blocks the phosphorylation of eIF4E in response to TNF-alpha, arsenite, anisomycin, PMA, or fetal calf serum in 293 cells (IC50 =...
| Keywords: | MNK1 Inhibitor, N3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine |
| Application: | MAPK-interacting kinase 1 inhibitor |
| CAS | 522629-08-9 |
| MW: | 244.2 D |
From 61.00€
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