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Item number: Cay30955-10

TGN 020 is an aquaporin-4 (AQP4) inhibitor (IC50 = 3.1 µM in X. laevis oocytes transfected with AQP4). It reduces brain edema and cortical infarction size in a mouse model of transient focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 200 mg/kg. TGN 020 (200...

Keywords:	N-1,3,4-thiadiazol-2-yl-3-pyridinecarboxamide
Application:	AQP4 inhibitor
CAS	51987-99-6
MW:	206.2 D

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TGN-020

Item number: TGM-T5102-100mg

Description: TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 µM), the most abundant water channel in the brain. Target: Aquaporin, PROTAC Linker. Smiles: O=C(Nc1nncs1)c1cccnc1. References: Huber VJ, et al. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg Med Chem. 2009...

Keywords:	TGN020
Application:	AQP4 inhibitor
CAS	51987-99-6
MW:	206.22 D

From 45.00€ *

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