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ESI-05
Item number: TGM-T15247-100mg
Description: ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 µM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation. Target: cAMP. Smiles: Cc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C. References: Tsalkova T, et al....
| Keywords: | NSC 116966 |
| Application: | Rap guanine nucleotide exchange factor 4 (Epac2) inhibitor |
| CAS | 5184-64-5 |
| MW: | 274.38 D |
From 34.00€
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ESI-05
Item number: Cay29702-1
ESI-05 is an inhibitor of exchange protein activated by cAMP 2 (Epac2) that inhibits cAMP-induced Epac2 guanine nucleotide exchange factor (GEF) activity with an IC50 value of 0.43 µM in a cell-free assay. It is selective for Epac2 over Epac1 and PKA at 25 µM. ESI-05 (1, 5, 10, and 25 µM) reduces activation of the...
| Keywords: | NSC 116966, 1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-benzene |
| Application: | Rap guanine nucleotide exchange factor 4 (Epac2) inhibitor |
| CAS | 5184-64-5 |
| MW: | 274.4 D |
From 44.00€
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