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Item number: Cay39719-1

Voclosporin is an immunosuppressant and a derivative of cyclosporin A (Cay-12088). It binds to cyclophilin A (Kd = 15 nM) and inhibits calcineurin activity in isolated human whole blood (IC50 = 120 ng/ml). Voclosporin reduces the proliferation of, and production of IL-2, IFN-gamma, and TNF-alpha in, isolated...

Keywords:	(E)-ISA247, trans-ISA 247, ISATX247, LX211, R-15424, 6-[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic...
Application:	Immunosuppressant, calcineurin inhibitor
CAS	515814-01-4
MW:	1214.6 D

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Voclosporin

Item number: TGM-T17235-100mg

Description: Voclosporin (ISAtx-247) is a novel, orally available calcium-modulated phosphatase (CN, PP2B) inhibitor and immunosuppressant used for treating lupus nephritis. Target: Phosphatase. Smiles:...

Keywords:	ISAtx-247
Application:	Immunosuppressant, Calcineurin inhibitor
CAS	515814-01-4
MW:	1214.62 D

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