Description: Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-kappaB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction. Target: NF-kappaB. Smiles: [NH4+].[S-]C(=S)N1CCCC1. References: Qin, J., Cao, Z., Li, X., Kang, X., Xue, Y., &...

Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-kappaB activation in vitro (100 µM). At 300 µM, it prevents TNF-alpha gene expression and protein production in human monocytes after LPS application. In vascular smooth muscle cells, PDTC (10 µM) arrests the...