An MC1R antagonist (IC50 = 7.23 nM), selective for MC1R over MC2R (IC50 = >10,000 nM) but does antagonize 5-HT2B and 5-HT1A receptors (IC50s = 9.66 and 16.9 nM, respectively), inhibits MCH-induced [35S]GTPgammaS binding and calcium influx in HEK293 cells expressing human MC1R at 3 nM, reduces stress-induced...

Description: ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affinity for MCH1R, MCH2R, MCH1, 5-HT2B receptors and 5-HT1A receptors with IC50s of 13.5 nM, >10,000 nM, 13 nM, 9.66 nM and 16.9 nM, respectively....