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Item number: Cay15115-10

TPCA-1 is a selective inhibitor of IkappaB kinase-2 (IC50s = 17.9 nM and 0.40 µM for IKK2 and IKK1, respectively). Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK. TPCA-1 inhibits the production of LPS-induced TNF-alpha, IL-6, and IL-8 with...

Keywords:	IKK2 Inhibitor IV, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
Application:	IkappaB kinase-2 inhibitor
CAS	507475-17-4
MW:	279.3 D

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