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HM03
Item number: TGM-T8668-100mg
Description: HM03 is a potent and selective inhibitor of HSPA5 and exhibits anticancer activity. Target: HSP. Smiles: COc1ccc2nc3cc(Cl)ccc3c(Nc3ccc(O)c(CN4CCN(C)CC4)c3)c2c1. References: Huang M , Li Z , Li D , et al. Structure-based design of HSPA5 inhibitors: From peptide to small molecule inhibitors[J]. Bioorganic...
| Application: | ERCC-1-XPF protein-protein interaction inhibitor, antibiotic |
| CAS | 500565-15-1 |
| MW: | 462.97 D |
From 42.00€
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HM03
Item number: Cay40908-10
HM03 is an inhibitor of the protein-protein interaction between the DNA excision repair protein ERCC-1 and the DNA repair endonuclease XPF (IC50 = 1.86 µM). It is also an inhibitor of D-alanine-D-alanine ligase B (DdlB, Ki = 218 µM for the E. coli enzyme). HM03 is active against E. coli and S. aureus (MICs = 64 and...
| Keywords: | 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol |
| Application: | ERCC-1-XPF protein-protein interaction inhibitor, antibiotic |
| CAS | 500565-15-1 |
| MW: | 463 D |
From 47.00€
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