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Item number: Cay30675-10

Proguanil is a prodrug form of the antimalarial agent cycloguanil (Cay-16861). Proguanil is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A to form cycloguanil in human liver microsomes. It is active against chloroquine- and quinine-resistant strains of P. falciparum alone or in combination with...

Keywords:	Chlorguanide, Chloroguanide, N-(4-chlorophenyl)-N'-(1-methylethyl)-imidodicarbonimidic diamide
Application:	Cycloguanil prodrug
CAS	500-92-5
MW:	253.7 D

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Proguanil

Item number: TGM-T22409-5mg

Description: Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction...

Keywords:	Chloroguanide , Chlorguanide
Application:	Targets dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45] (DHFR-TS)
CAS	500-92-5
MW:	253.73 D

From 34.00€ *

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