Eltrombopag is an orally bioavailable nonpeptide agonist of the thrombopoietin receptor (EC50 = 0.27 µM in a reporter assay) and an iron chelator. It increases STAT5 phosphorylation in N2C-Tpo cells when used at a concentration of 30 µM and p42/44 MAPK phosphorylation when used at 10 µM. Eltrombopag binds to the...

Description: Eltrombopag (SB-497115-GR), an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the platelet thrombopoietin receptor (TPO-R or CD110). Target: Thrombin. Smiles: O=C/1N(N=C(C)\C1=N\NC2=C(O)C(=CC=C2)C3=CC(C(O)=O)=CC=C3)C4=CC(C)=C(C)C=C4....