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Item number: Cay16771-5

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFalpha component (a RUNX protein) and an enhancer of binding, CBFbeta. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFbeta inhibitor is a small molecule that binds to CBFbeta...

Keywords:	Core Binding Factor-beta Inhibitor, 5-ethyl-4-(4-methoxyphenyl)-2-thiazolamine
Application:	CBFbeta-Runx1 interaction inhibitor
CAS	493028-20-9
MW:	234.3 D

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CBFbeta Inhibitor

Item number: TGM-T22195-10mg

Description: CBFbeta Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFbeta inhibitor and inhibits its association with Runx1. Target: DNA/RNA Synthesis. Smiles: CCC1=C(N=C(N)S1)C1=CC=C(OC)C=C1. References: Michael J Gorczynskir, et al.Allosteric inhibition of the protein-protein...

Keywords:	5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
Application:	CBFbeta inhibitor
CAS	493028-20-9
MW:	234.32 D

From 29.00€ *

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