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SB-674042
Item number: Cay21270-1
SB-674042 is a potent and selective non-peptide orexin 1 receptor (OX1R) antagonist (Kd = 5.03 and 3.76 nM in whole cell binding and membrane-based assays, respectively). In calcium mobilization studies, it was >100-fold selective for OX1 over OX2 and did not show significant affinity for serotonergic, dopaminergic,...
| Keywords: | [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]-methanone |
| Application: | OX1 receptor antagonist |
| CAS | 483313-22-0 |
| MW: | 448.5 D |
From 52.00€
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SB-674042
Item number: TGM-T16854-1mg
Description: SB-674042 is a potent, selective dual antagonist of the non-peptide orexigenic peptides OX1 and OX2 receptors, with IC50 values of 3.76 nM and 531 nM, respectively. SB-674042 is suitable for the treatment of depression. Target: OX Receptor. Smiles:...
| Keywords: | SB674042 |
| Application: | OX1 receptor antagonist |
| CAS | 483313-22-0 |
| MW: | 448.51 D |
From 43.00€
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