2 products were found matching "459868-92-9"!

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Item number: Cay11570-1

Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins. Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is...

Keywords:	AG-014699, PF-01367338,...
Application:	PARP-1 inhibitor
CAS	459868-92-9
MW:	421.4 D

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Rucaparib Phosphate

Item number: TGM-T6127-100mg

Description: Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy. Target: PARP. Smiles: OP(O)(O)=O.CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23. References: Thomas HD, et al. Preclinical selection of a...

Keywords:	AG-014699 phosphate, PF-01367338, AG-014699, PF-01367338 phosphate
Application:	Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1)
CAS	459868-92-9
MW:	421.36 D

From 31.00€ *

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