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GW788388
Item number: TGM-T1800-100mg
Description: GW788388 is a potent and selective inhibitor of ALK5, and it also inhibits TGF-(beta) type II receptor and activin type II receptor activities. Target: ALK, TGF-beta/Smad. Smiles: O=C(NC1CCOCC1)c1ccc(cc1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1. References: Gellibert F, et al. J Med Chem. 2006, 49(7), 2210-2221.
| Keywords: | GW 788388 |
| Application: | TGFBR1 / ALK5 inhibitor |
| CAS | 452342-67-5 |
| MW: | 425.48 D |
From 58.00€
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GW 788388
Item number: Cay16255-1
GW 788388 is a selective inhibitor of transforming growth factor-beta (TGF-beta) type 1 receptor (TGFBR1 or ALK5, IC50 = 18 nM). It inhibits the expression of collagen type I in cells (IC50 = 93 nM) and in mice when given orally at 10 mg/kg once a day. As TGF-beta stimulates fibrosis in a range of tissues, GW 788388...
| Keywords: | 4-[4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide |
| Application: | TGFBR1 / ALK5 inhibitor |
| CAS | 452342-67-5 |
| MW: | 425.5 D |
From 78.00€
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GW-788388
Item number: LKT-G8800.1
ALK5 (activin-like) antagonist.
| Application: | ALK5 (activin-like) antagonist |
| CAS | 452342-67-5 |
| MW: | 425.49 D |
From 104.00€
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