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ALK5 Inhibitor II
Item number: Cay14794-25
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when...
| Keywords: | E 616452, RepSox, SJN 2511, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
| Application: | ALK5 inhibitor |
| CAS | 446859-33-2 |
| MW: | 287.3 D |
From 36.00€
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RepSox
Item number: TGM-T6337-100mg
Description: RepSox (ALK5 Inhibitor II) is a TGFbetaR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells. Target: TGF-beta/Smad, ALK. Smiles: Cc1cccc(n1)-c1n[nH]cc1-c1ccc2ncccc2n1. References: Tu WZ, et...
| Keywords: | ALK5 Inhibitor II, E-616452, SJN 2511 |
| Application: | ALK5 inhibitor |
| CAS | 446859-33-2 |
| MW: | 287.32 D |
From 31.00€
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![RepSox (2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine, E-616452)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg "RepSox (2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine, E-616452)")
RepSox...
Item number: R1035-85.1
Cell-permeable. A TGF-b type I receptor (ALK5) inhibitor. Inhibits ALK5 autophosphorylation (IC??=4nM). Can replace one of the four reprogramming factors Sox-2. RepSox has been successfully used in the direct reprogramming of mouse fibroblasts through induction of Nanog transcription. Solubility: DMSO (>20mg/ml),...
| CAS | 446859-33-2 |
| MW: | ~287.32 kD |
From 139.00€
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