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Item number: Cay18494-1

JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDKs) and Aurora kinases. It potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Cdk6/cyclin D1, Aurora A, and Aurora B in vitro (IC50s = 9, 4, 3, 58, 253, 175, 11, and 15 nM, respectively). It shows selectivity...

Keywords:	Aurora A Inhibitor I, Aurora Kinase/CDK Inhibitor,...
Application:	Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Aurora A/B inhibitor
CAS	443797-96-4
MW:	394.4 D

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JNJ-7706621

Item number: SYN-1048-M001

Soluble in DMSO or ethanol. JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDK) and aurora kinases. It demonstrates highest potency on CDK1/2 with IC(50) values of 9nM and 4nM respectively. It shows more than 6-fold selectivity for CDK1/2 over CDK3/4/6. Target: Aurora - CDK , Kinase Group: Other ,...

Keywords:	JNJ7706621
Application:	Aurora / CDK1 / CDK2 inhibitor
CAS	443797-96-4
MW:	394,4 D

From 165.00€ *

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