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BMS 509744
Item number: Cay34148-1
An Itk inhibitor (IC50 = 19 nM), selective for Itk over 18 other kinases (IC50s = >1,100 nM for all), inhibits IL-2 secretion from Jurkat T cells and isolated human PBMCs induced by antibodies targeting CD3 (IC50s = 0.25 and 0.39 µM, respectively), decreases serum levels of Il-2 and the lung infiltration of total...
| Keywords: | N-[5-[[5-[(4-acetyl-1-piperazinyl)carbonyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[[(1,2,2-trimethylpropyl)amino]m... |
| Application: | Itk inhibitor |
| CAS | 439575-02-7 |
| MW: | 623.83 D |
From 52.00€
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BMS-509744
Item number: TGM-T14674-100mg
Description: BMS-509744 is an inhibitor of ATP competitive Itk (IC50: 19 nM). Target: Others. Smiles: C(=O)(C1=C(OC)C=C(C)C(SC=2SC(NC(=O)C3=CC=C(CNC(C(C)(C)C)C)C=C3)=NC2)=C1)N4CCN(C(C)=O)CC4. References: Lin TA, et al. Selective Itk inhibitors block T-cell activation and murine lung inflammation. Biochemistry.?2004...
| CAS | 439575-02-7 |
| MW: | 623.83 D |
From 652.00€
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