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Item number: Cay19999-1

SJ 172550 is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM. It forms a covalent, but reversible, cysteine adduct in the MDMX p53-binding domain, locking MDMX into a conformation that prevents binding to p53. SJ 172550 induces apoptosis, increases p53 target gene...

Keywords:	MDMX Inhibitor II,...
Application:	MDM4 inhibitor
CAS	431979-47-4
MW:	428.9 D

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SJ-172550

Item number: TGM-T16888-100mg

Description: SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 µM). Target: Mdm2, E1/E2/E3 Enzyme. Smiles: CCOc1cc(\C=C2/C(C)=NN(C2=O)c2ccccc2)cc(Cl)c1OCC(=O)OC. References: Reed D, et al. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem. 2010 Apr...

Application:	MDM4 inhibitor
CAS	431979-47-4
MW:	428.87 D

From 36.00€ *

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