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PYZD-4409
Item number: Cay44131-10
PYZD-4409 is an inhibitor of ubiquitin-activating enzyme (UAE, IC50 = 20 µM in a cell-free assay). It decreases levels of ubiquitinated cell division cycle 34 (Cdc34) in K562 chronic myeloid leukemia (CML) cells when used at a concentration of 50 µM. PYZD-4409 increases levels of cyclin D3 and p53 in HCT116...
| Keywords: | 1-(3-chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione |
| Application: | UAE inhibitor |
| CAS | 423148-78-1 |
| MW: | 351.67 D |
From 127.00€
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PYZD-4409
Item number: TGM-T16699-100mg
Description: PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 µM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells. Target: E1/E2/E3 Enzyme, Others. Smiles: [O-][N+](=O)c1ccc(\C=C2\C(=O)NN(C2=O)c2ccc(F)c(Cl)c2)o1....
| CAS | 423148-78-1 |
| MW: | 351.67 D |
From 31.00€
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