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PYR41
PYR41

Item number: Cay15226-1

PYR41 is an irreversible inhibitor of ubiquitin-activating enzyme (E1) with an IC50 value of less than 10 µM. PYR41 specifically inhibits ubiquitin-thioester bond formation (IC50 = 6.4 µM) and not adenylation. It is selective for E1 over ubiquitin-conjugating enzyme (E2) but does inhibit autoubiquitination of the...
Keywords: 4-[4-[(5-nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]-benzoic acid, ethyl ester
Application: Cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor
CAS 418805-02-4
MW: 371.3 D
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