3 products were found matching "415903-37-6"!
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Grapiprant
Item number: LKT-G681019.100
Grapiprant is an orally bioavailable antagonist of the prostaglandin E receptor subtype 4 (EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon administration of grapiprant, this agent selectively binds to and inhibits the binding of prostaglandin E2 (PGE2) and prevents the activation...
| Keywords: | CJ-023423, RQ-00000007, AAT-007,... |
| Application: | EP4 receptor antagonist |
| CAS | 415903-37-6 |
| MW: | 491.61 D |
From 150.00€
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Grapiprant
Item number: TGM-TQ0292-100mg
Description: Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM). Target: Prostaglandin Receptor. Smiles: CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1. References: Vito VD, et al....
| Keywords: | AAT-007, CJ-023423, RQ-00000007 |
| Application: | Targets prostaglandin E receptor 4 (PTGER4) |
| CAS | 415903-37-6 |
| MW: | 491.61 D |
From 31.00€
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CJ-023423
Item number: Cay10010355-1
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki =...
| Keywords: | Grapiprant, RQ-00000007,... |
| Application: | EP4R antagonist |
| CAS | 415903-37-6 |
| MW: | 491.6 D |
From 44.00€
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