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Item number: Cay28431-1

GW 766994 is an antagonist of chemokine (C-C motif) receptor 3 (CCR3) with a Ki value of 13.8 nM in an assay of eosinophil chemotaxis induced by chemokine (C-C motif) ligand 11 (CCL11). It decreases CCL11-induced cyclin-dependent kinase 5 (Cdk5) and tau phosphorylation and production of amyloid beta (1-42) (Abeta42)...

Keywords:	GW 994, 4-[[[[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]carbonyl]amino]methyl]-benzamide
Application:	CCR3 antagonist
CAS	408303-43-5
MW:	451.4 D

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GW 766994

Item number: TGM-T11521-100mg

Description: GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment. Target: CCR. Smiles: NC(=O)c1ccc(CNC(=O)NC[C@H]2CN(Cc3ccc(Cl)c(Cl)c3)CCO2)cc1. References: Neighbour H, et al. Safety and efficacy of an oral CCR3 antagonist in...

Keywords:	GW 994
CAS	408303-43-5
MW:	451.35 D

From 1,137.00€ *

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