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A-385358
Item number: Cay43417-1
A Bcl-xL inhibitor (Ki = 0.8 nM), selective for Bcl-xL over Bcl-2 (Ki = 67 nM), decreases the proliferation of NCI H146, MOLT-4, and CCRF CEM cells in serum-free media (IC50s = 0.35, 0.74, and 0.21 µM, respectively), reduces tumor growth at 100 mg/kg per day in combination with paclitaxel in an A549 lung cancer...
| Keywords: | N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-4-(4,4-dimethyl-1-piperidinyl)-... |
| Application: | Bcl-xL inhibitor |
| CAS | 406228-55-5 |
| MW: | 639.83 D |
From 73.00€
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A-385358
Item number: TGM-T14071-100mg
Description: A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 nM for Bcl-2, respectively. Target: BCL. Smiles: CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(C)(C)CC1. References: Shoemaker AR, et al. A small-molecule inhibitor of Bcl-XL potentiates the...
| CAS | 406228-55-5 |
| MW: | 639.83 D |
From 52.00€
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