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Item number: Cay14504-1

ACHP is an inhibitor of IkappaB kinase beta (IKKbeta) and IKKalpha (IC50s = 8.5 and 250 nM, respectively). It is selective for IKKbeta and IKKalpha over IKKgamma, Syk, and MKK4 (IC50s = >20 µM for all). It reduces the constitutive phosphorylation of IkappaBalpha and NF-kappaB p65 in U266 and NCU-MM-2 multiple...

Keywords:	2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile
Application:	IKKbeta / IKKalpha inhibitor
CAS	406208-42-2
MW:	364.4 D

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ACHP

Item number: TGM-T22021-25mg

Description: ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-alpha and IKK-beta. ACHP has anti-HIV-1 activity and inhibits HIV-1 long terminal repeat (LTR)-driven gene expression through inhibition of NF-kappaB activation, inhibits TNF-alpha-induced NF-kappaB...

Keywords:	IKK-2 Inhibitor VIII
CAS	406208-42-2
MW:	364.44 D

From 46.00€ *

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