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Item number: Cay14522-5

ONO-AE3-208 is an antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors. In wild type mice, it mimics deletion of EP4 by producing severe colitis, with epithelial loss, crypt...

Keywords:	4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-benzenebutanoic acid
Application:	EP4 receptor antagonist
CAS	402473-54-5
MW:	404.4 D

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ONO-AE3-208

Item number: TGM-TQ0290-100mg

Description: ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer. Target: Prostaglandin Receptor. Smiles: CC(C(=O)Nc1cc(ccc1CCCC(O)=O)C#N)c1ccc(F)c2ccccc12. References: Xu S, et al. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration,...

Keywords:	AE 3-208
Application:	EP4 receptor antagonist
CAS	402473-54-5
MW:	404.43 D

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