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Item number: TGM-T6152-100mg

Description: PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. Target: MEK. Smiles: OCC(O)CONC(=O)c1cc(Br)c(F)c(F)c1Nc1ccc(I)cc1F. References: Ohren JF, et al. Nat Struct Mol Biol, 2004, 11(12),...

Application:	Allosteric MEK1 inhibitor
CAS	391210-00-7
MW:	561.09 D

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PD 318088

Item number: Cay30265-1

PD 318088 is an allosteric inhibitor of MEK1 and an analog of the MEK inhibitor PD 184352 (CI-1040, Cay-11580). PD318088 binds to MEK1 concurrently with Mg-ATP and stabilizes an inactive conformation of MEK1, as well as prevents formation of tetramers and higher-order oligomers.Formal Name:...

Keywords:	5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
Application:	Allosteric MEK1 inhibitor
CAS	391210-00-7
MW:	561.1 D

From 61.00€ *

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