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Item number: Cay29482-10

GS-39783 is a positive allosteric modulator of GABAB receptors that potentiates GABA-stimulated [35S]GTPgammaS binding to recombinant human GABAB receptors and rat cortical membranes (EC50s = 2.1 and 3.1 µM, respectively). It amplifies GABAB receptor-mediated transient calcium signaling in HEK293 cells expressing...

Keywords:	N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
Application:	GABA-B receptor positive allosteric modulator
CAS	39069-52-8
MW:	337.4 D

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GS 39783

Item number: TGM-T22813-100mg

Description: GS 39783 is a positive allosteric modulator (PAM) of GABABR, which reduces the motivational properties of alcohol and the conditioned reinforcement and conditional reward of psychostimulants. Target: GABA Receptor. Smiles: N(C=1C(N(=O)=O)=C(NC2CCCC2)N=C(SC)N1)C3CCCC3. References: Emmanuel Sturchler, et...

CAS	39069-52-8
MW:	337.44 D

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