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Item number: Cay45715-10

Coralyne is a DNA topoisomerase I poison. It inhibits DNA topoisomerase I via stabilization of the DNA-enzyme complex and inhibition of DNA relaxation. It is selective for DNA topoisomerase I over DNA topoisomerase II at 100 µg/ml. Coralyne (100-400 mg/kg) increases survival in P388 and L1210 murine leukemia...

Keywords:	2,3,10,11-tetramethoxy-8-methyl-dibenzo[a,g]quinolizinium, monochloride
Application:	DNA topoisomerase I poison
CAS	38989-38-7
MW:	399.87 D

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Coralyne chloride

Item number: TGM-T31011-100mg

Description: Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. It acts as a topoisomerase I toxic molecule, inducing topoisomerase I-mediated DNA...

CAS	38989-38-7
MW:	399.87 D

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