Description: Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-kappaB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities. Target: HSP, Apoptosis, Mdm2, NF-kappaB. Smiles:...

Triptolide is a diterpenoid triepoxide that has been found in T. wilfordii and has diverse biological activities. It inhibits dCTP pyrophosphatase 1 (Ki = 168 µM), an enzyme that prevents halogenated nucleotides from entering DNA synthesis. It reduces viability of A549, H1299, NCI H520, NCI H1650, and H1975 human...

Crystalline solid. Soluble in DMSO. Sparingly soluble in ethanol. Potent immunosuppressant with anti-inflammatory and antitumor properties, Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators, Inhibits global gene transcription by inducing degradation...

Is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordi. It has an inhibitory activity on breast stomach and leukemia cell line HL-60 cells. Triptolide induces apoptosis in tumor cells by blocking NF-kB activation and sensitizing tumor cells for TNF-alpha induced...

White to off-white powder. Soluble in DMSO. Chemical. CAS: 38748-32-2. Formula: C20H24O6. MW: 360.4. Synthetic. Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits...