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Adaptaquin
Adaptaquin

Item number: Cay19720-5

Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 2 micromolar). It stabilizes HIF-1alpha protein and induces expression of the HIF-1-regulated genes EPO and VEGF in SH-SY5Y human neuroblastoma cells. Adaptaquin protects against cell death induced by glutathione depletion...
Keywords: 7-[(4-chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Application: Hypoxia-inducible factor prolyl hydroxylase inhibitor
CAS 385786-48-1
MW: 377.8 D
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