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Item number: TGM-T16357-1mg

Description: DA-3003-1 (DA-3003-1) is a membrane-permeable, potent and selective Cdc25 dual specificity phosphatase inhibitor with antitumor activity that inhibits Cdc25B2, Cdc25A, Cdc25B2 and Cdc25C. Target: Phosphatase. Smiles: ClC1=C(NCCN2CCOCC2)C(=O)c2ncccc2C1=O. References: Guo J, et al. Pharmacology and...

Keywords:	NSC 663284
Application:	Cdc25 inhibitor
CAS	383907-43-5
MW:	321.76 D

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NSC 663284

Item number: Cay13303-1

Three genes encode dual specificity phosphatases that are Cdc25 homologs. The phosphatases, Cdc25A through C, are proto-oncogenes and are often over-expressed in cancers. NSC 663284 is a potent, cell-permeable, and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC50 = 29, 95, and 89 nM for...

Keywords:	Cdc25 Phosphatase Inhibitor II, DA-3003-1, SPS8I1, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
Application:	Cdc25 inhibitor
CAS	383907-43-5
MW:	321.8 D

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