Description: PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53. Target: DNA Alkylator/Crosslinker. Smiles: CS(=O)(=O)c1ncc(Cl)c(n1)C(O)=O. References: Bauer MR, et al. 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells....

PK11000 is a stabilizer of mutant p53. It covalently binds to Cys182 and Cys277, increases the thermal stability, and inhibits the aggregation of the p53Y220C DNA-binding domain when used at a concentration of 1 mM. PK11000 selectively decreases the viability of mutant p53-expressing SW480 (p53R273H,P309S), NUGC-3...