IC-87114 is a cell-permeable selective inhibitor of the PI3K catalytic subunit p110delta (IC50 = 0.5 µM). It less effectively inhibits p110gamma and p110beta (IC50 = 29 and 75 µM, respectively) and has no significant effect on p110alpha and several other kinases. This product is used to elucidate the role of...

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. IC87114 is a potent, ATP-competitive, and selective inhibitor of PI3Kdelta. IC(50) values (130-500nM) for IC87114 are sub-micromolar over a wide range of ATP concentrations from 10µM to 200µM. IC87114 can selectively inhibit cellular migration but not...

IC-87114 is an inhibitor of p110 PI3K that exhibits anti-inflammatory, immunosuppressive, anti-asthma, anti-angiogenic, and anti-diabetic activities. In animals, IN-87114 inhibits airway infiltration of lymphocytes, neutrophils, and eosinophils, decreases expression of IL-4, IL-5, IL-13, and IL-17, and prevents...