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Mubritinib
Item number: TGM-T6124-100mg
Description: Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM. Target: FGFR, JAK, EGFR, PDGFR. Smiles: FC(F)(F)c1ccc(\C=C\c2nc(COc3ccc(CCCCn4ccnn4)cc3)co2)cc1. References: Nagasawa J, et al. Int J Urol, 2006, 13(5), 587-592.
| Keywords: | TAK-165 |
| Application: | Targets receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1] (ERBB2, HER2, CD340) |
| CAS | 366017-09-6 |
| MW: | 468.47 D |
From 206.00€
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Mubritinib, Free base
Item number: LKT-M8007.5
A protein kinase inhibitor. It inhibits HER2, human epidermal growth factor receptor 2 tyrosine kinase.
| Keywords: | TAK-165 |
| Application: | HER2 inhibitor |
| CAS | 366017-09-6 |
| MW: | 468,47 D |
From 187.00€
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Mubritinib
Item number: Cay12096-5
Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM. It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 µM). Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer...
| Keywords: | TAK-165, 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole |
| Application: | HER2 inhibitor |
| CAS | 366017-09-6 |
| MW: | 468.5 D |
From 54.00€
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![Mubritinib, Free Base (1-[4-[4-[[2-[(1E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]ph](https://www.biomol.com/media/image/0e/d0/43/M9202-50-10_200x200.jpg "Mubritinib, Free Base (1-[4-[4-[[2-[(1E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]ph")
Mubritinib, Free Base...
Item number: M9202-50.10
Mubritinib is a potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase. For inhibitory testing, HER2 was expressed in the following cell types: bladder (HT1376, UMUC3, T24), kidney (ACHN), and prostate (DU145, LNCaP, LN-REC4). IC50 values for mubritinib for the bladder cancer cell...
| CAS | 366017-09-6 |
| MW: | 468.47 |
236.00€
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Mubritinib
Item number: AG-CR1-3755-M005
Mubritinib (TAK-165) is a selective inhibitor of the human epidermal growth factor receptor 2 (EGFR2, HER2), inhibiting HER2 phosphorylation with an IC50 value of 6nM. It is 4000-fold selective over EGFR, FGFR, PDGFR, JAK1, Src and Blk (IC50 > 25µM). Mubritinib inhibits the proliferation of breast, bladder, kidney...
| Keywords: | TAK-165, TAK 165, CID 6444693 |
| Application: | Antineoplastic, Receptor tyrosine kinase inhibitor |
| CAS | 366017-09-6 |
| MW: | 468.5 D |
From 33.00€
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