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Item number: Cay14611-1

AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Delta7-reductase (DHCR7) enzyme (IC50 = 13 nM), which interferes with the conversion of 7-dehydro cholesterol (Cay-14612) to cholesterol. Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the...

Keywords:	trans-N1,N4-bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine, dihydrochloride
Application:	DHCR7 inhibitor
CAS	366-93-8
MW:	464.3 D

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