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A 419259
Item number: TGM-T10206-2mg
Description: A 419259 is a pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family (IC50s: 9 nM, <3 nM and <3 nM for Src, Lck and Lyn). Target: Src. Smiles: NC1=C2C(=CN(C2=NC=N1)[C@H]3CC[C@@H](CC3)N4CCN(C)CC4)C5=CC=C(OC6=CC=CC=C6)C=C5. References: Wilson MB, et al. Selective...
| Keywords: | RK-20449 |
| CAS | 364042-47-7 |
| MW: | 482.62 D |
67.00€
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A-419259
Item number: Cay25605-1
A-419259 is an inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, 50 = 3,000 nM) and PKC (IC50 = >33 µM). A-419259 inhibits growth of Philadelphia chromosome-positive (Ph+) K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 µM, respectively), but not Ph- TF-1 and HEL cells....
| Keywords: | RK-20449, 7-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Application: | Src family kinase inhibitor |
| CAS | 364042-47-7 |
| MW: | 482.6 D |
From 111.00€
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