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SB 525334
Item number: TGM-T1763-5mg
Description: SB-525334 is a potent and selective inhibitor of the TGF-beta1R and ALK5 (IC50: 14.3 nM). Target: ALK, TGF-beta/Smad. Smiles: C(C)(C)(C)C=1NC(=C(N1)C=2N=C(C)C=CC2)C3=CC4=C(C=C3)N=CC=N4. References: Grygielko ET, et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth...
| Keywords: | SB525334 |
| Application: | TGFBR1 inhibitor |
| CAS | 356559-20-1 |
| MW: | 343.42 D |
From 33.00€
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SB-525334
Item number: Cay16281-1
SB-525334 is a potent inhibitor of the TGF-beta receptor 1 (TGF-beta R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. SB-525334 blocks TGF-beta1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-beta1-directed gene...
| Keywords: | TGF-beta RI Kinase Inhibitor VIII, 6-[2-(1,1-dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]-quinoxaline |
| Application: | TGFBR1 inhibitor |
| CAS | 356559-20-1 |
| MW: | 343.4 D |
From 45.00€
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