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Item number: Cay16281-1

SB-525334 is a potent inhibitor of the TGF-beta receptor 1 (TGF-beta R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. SB-525334 blocks TGF-beta1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-beta1-directed gene...

Keywords:	TGF-beta RI Kinase Inhibitor VIII, 6-[2-(1,1-dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]-quinoxaline
Application:	TGFBR1 inhibitor
CAS	356559-20-1
MW:	343.4 D

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