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PJ-34 (hydrochloride)
Item number: Cay14440-5
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. PJ-34 is an inhibitor of PARPs which can be used in cells or in animals. It binds and inhibits the PARP tankyrase1 (IC50 = 1 µM). PJ-34 also...
| Keywords: | N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-acetamide, monohydrochloride |
| Application: | PARP inhibitor |
| CAS | 344458-15-7 |
| MW: | 331.8 D |
From 56.00€
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PJ-34
Item number: AG-CR1-0100-M005
Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor, Inhibits peroxynitrite-induced cell necrosis, Shows significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models, Provides cardioprotection by decreasing myocardial infarct size, Shows protective effects in models...
| Keywords: | PJ34, N-(6-Oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide . HCl |
| Application: | PARP inhibitor |
| CAS | 344458-15-7 |
| MW: | 295,2 D |
From 44.00€
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PJ34 HCl
Item number: LKT-P3600.1
PJ34 is a phenanthridinone derivative that acts as a competitive poly(ADP)-ribose polymerase (PARP) inhibitor. PJ34 exhibits cardioprotective, neuroprotective, anticancer, and anti-diabetic activities. In in vitro and in vivo models of oxygen glucose deprivation, PJ34 protects against stroke-related ischemic brain...
| Application: | PARP inhibitor |
| CAS | 344458-15-7 |
| MW: | 331.8 D |
From 128.00€
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PJ34 hydrochloride
Item number: TGM-T2124-100mg
Description: PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2. Target: PARP. Smiles: Cl.CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1. References: Garcia Soriano F, et al. Nat Med, 2001, 7(1), 108-113.
| Keywords: | PJ34 HCl |
| CAS | 344458-15-7 |
| MW: | 331.8 D |
From 32.00€
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