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KRIBB11
Item number: Cay9002528-5
KRIBB11 is an inhibitor of heat shock factor 1 (Hsf1) with an IC50 value of 1.2 µM in a luciferase reporter assay. It blocks heat shock-induced Hsp70, Hsp40, and Hsp27 mRNA expression and down-regulates protein expression of the Hsf1 target proteins Hsp70 and Hsp27 in HCT116 cells in a dose-dependent manner. KRIBB11...
| Keywords: | N2-1H-indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine |
| Application: | Hsf1 inhibitor |
| CAS | 342639-96-7 |
| MW: | 284.3 D |
From 93.00€
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KRIBB11
Item number: TGM-T3652-100mg
Description: KRIBB11 is an inhibitor of Heat Shock Factor (HSF) [inhibitor]. Target: Apoptosis, HSP. Smiles: CNc1ccc(c(Nc2ccc3[nH]ncc3c2)n1)[N+]([O-])=O. References: Yoon YJ, et al. J Biol Chem. 2011, 286(3):1737-47.
| Application: | Hsf1 inhibitor |
| CAS | 342639-96-7 |
| MW: | 284.27 D |
From 45.00€
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