Description: 1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor-gated currents. Target: GluR, iGluR. Smiles: O=C(N1CCCCC1)c1ccc2OCOc2c1. References: Yamada K A . AMPA receptor activation potentiated by the AMPA modulator 1-BCP is toxic to cultured rat hippocampal neurons[J]....

1-BCP is a positive allosteric modulator of AMPA receptors. 1-BCP (1 mM) selectively increases the release of norepinephrine induced by AMPA, but not NMDA or kainic acid, in rat hippocampal slices. It increases the amplitude and duration of primed field excitatory postsynaptic potentials (EPSPs) in rat hippocampal...